Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells

Title
Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells
Author(s)
체타라비쉬누프라사드T. Anjana[T. Anjana]Asoke Banerji[Asoke Banerji]Anilkumar Gopalakrishnapillai[Anilkumar Gopalakrishnapillai]
Keywords
PROTEIN-KINASE-C; HIPPOPHAE-RHAMNOIDES; INSULIN-RESISTANCE; PHOSPHATIDYLINOSITOL 3-KINASE; BAUHINIA-FORFICATA; SKELETAL-MUSCLE; RAT ADIPOCYTES; ADIPOSE-CELLS; DIABETIC RATS; TANNIC-ACID
Issue Date
201001
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.584, no.3, pp.531 - 536
Abstract
GLUT4, a 12 transmembrane protein, plays a major role in insulin mediated glucose transport in muscle and adipocytes. For glucose transport, the GLUT4 protein needs to be translocated to the plasma membrane from the intracellular pool and it is possible that certain compounds may be able to enhance this process. In the present work, we have shown that gallic acid can increase GLUT4 translocation and glucose uptake activity in an Akt-independent but wortmannin-sensitive manner. Further analysis suggested the role of atypical protein kinase C zeta/lambda in gallic acid mediated GLUT4 translocation and glucose uptake. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/23001http://dx.doi.org/10.1016/j.febslet.2009.11.092
ISSN
0014-5793
Appears in Collections:
중앙도서관 > rims journal
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