Enantioseparation of Neutral Compounds on a Quinine Carbamate-Immobilized Zirconia in Reversed-Phase Capillary Electrochromatography

Title
Enantioseparation of Neutral Compounds on a Quinine Carbamate-Immobilized Zirconia in Reversed-Phase Capillary Electrochromatography
Author(s)
박정학이문락[이문락]권주림[권주림]
Keywords
CHIRAL STATIONARY PHASES; PERFORMANCE LIQUID-CHROMATOGRAPHY; 2,4-DINITROPHENYL AMINO-ACIDS; CARBON-CLAD ZIRCONIA; ANION-EXCHANGERS; CARBAMOYLATED QUININE; ELECTROOSMOTIC FLOW; CINCHONA ALKALOIDS; MAGNESIA-ZIRCONIA; SEPARATION
Issue Date
201001
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.31, no.1, pp.82 - 86
Abstract
Quinine (QN) is a weak anion-exchange type chiral selector and QN-based silica stationary phases have been widely used for enantioseparation of acidic chiral analytes in HPLC and recently in CEC. In this work we report enantioseparation of non-acidic chiral analytes on a quinine carbamate-immobilized zirconia (QNZ) ill reversed-phase (RP) CEC. Influences of pH, composition of the buffer, acetonitrile content and the applied voltage on enantioseparation were examined. Enantiomers of the analytes investigated are well separated in acetonitrile/phosphate buffer mobile phases. Separation data on QNZ were compared to those on QN-bonded silica (QNS). Retention was longer but better enantioselectivity and resolution were obtained on QNZ than QNS.
URI
http://hdl.handle.net/YU.REPOSITORY/22999http://dx.doi.org/10.5012/bkcs.2010.31.01.082
ISSN
0253-2964
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이과대학 > 화학생화학부 > Articles
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