Two novel neo-clerodane diterpenoids from Scutellaria barbata

Title
Two novel neo-clerodane diterpenoids from Scutellaria barbata
Author(s)
심상희이한나[이한나]김유진[김유진]최인호민병선[민병선]
Keywords
CYTOTOXIC ACTIVITIES; ALKALOIDS; CONSTITUENTS
Issue Date
201001
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.1, pp.288 - 290
Abstract
Two novel neo-clerodane diterpenoids, barbatellarines A (1) and B (2), were isolated from the whole plants of Scutellaria barbata, along with the known compound scutebarbatine F (3). The chemical structures and relative stereochemistry of the isolated compounds were established by NMR (1D and 2D) and mass spectroscopic analyses. Compounds 2 and 3 were evaluated for in vitro cytotoxic activity against the HL-60 (human leukemia), MCF7 (human breast cancer), and LLC (Lewis lung carcinoma) cancer cell lines. Compound 2 exhibited weak cytotoxic activity against HL-60 cells, with an IC(50) value of 41.4 mu M. (c) 2009 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/22991http://dx.doi.org/10.1016/j.bmcl.2009.10.116
ISSN
0960-894X
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생명공학부 > 생명공학부 > Articles
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