Discorhabdins from the Korean Marine Sponge Sceptrella sp.

Title
Discorhabdins from the Korean Marine Sponge Sceptrella sp.
Author(s)
남기평오기봉[오기봉]전주은[전주은]나제연[나제연]정미송[정미송]이희성[이희성]심정자[심정자]신종헌[신종헌]
Keywords
CIRCULAR-DICHROISM SPECTRA; PYRROLOIMINOQUINONE ALKALOIDS; CYTOTOXIC ALKALOIDS; LATRUNCULIA-BREVIS; ZYZZYA-FULIGINOSA; GENUS LATRUNCULIA; NATURAL-PRODUCTS; MAKALUVAMINES; METABOLITES; PIGMENT
Issue Date
201002
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.73, no.2, pp.258 - 262
Abstract
Two new pyrroloiminoquinone alkaloids of the discorhabdin class. along with 12 compounds including one previously described synthetic derivative of the same and related skeletal classes, were isolated from the sponge Sceptrella sp., collected from Gageodo, Korea. The structures of these new compounds. designated as (-)-3-dihydrodiscorhabdin D (11) and (-)-discorhabdin Z (12), were determined by combined spectroscopic analyses. Compound 12 possesses all unusual hemiaminal group among the discorhabdin alkaloids. These compounds exhibited moderate to significant cytotoxicity, antibacterial activity, and inhibitory activity against sortase A.
URI
http://hdl.handle.net/YU.REPOSITORY/22897http://dx.doi.org/10.1021/np9005629
ISSN
0163-3864
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이과대학 > 화학생화학부 > Articles
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