The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens

Title
The antimicrobial activity of compounds from the leaf and stem of Vitis amurensis against two oral pathogens
Author(s)
나민균임남희[임남희]Do Thi Ha[Do Thi Ha]Trinh Nam Trung[Trinh Nam Trung]김진표[김진표]이상명[이상명]정현주[정현주]김현수[김현수]김영호[김영호]배기환[배기환]
Keywords
RESVERATROL OLIGOMERS; OLIGOSTILBENES; POLYPHENOLS; ANTIOXIDANT; EXTRACTS; MUTANS; CELLS
Issue Date
201002
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.3, pp.1165 - 1168
Abstract
Nine compounds isolated from the leaf and stem of Vitis amurensis Rupr. (Vitaceae) were evaluated for their antimicrobial activity against two oral pathogens, Streptococcus mutans and Streptococcus sanguis, which are associated with caries and periodontal disease, respectively. The results of several antimicrobial tests, including MIC, MBC, and TBAI, showed that three compounds inhibited the growth of the test bacteria at concentrations ranging from 12.5 to 50 mu g/mL. Among these compounds, compound 5, trans-epsilon-viniferin, displayed the strongest activity against S. mutans and S. sanguis with MIC values of 25 and 12.5 mu g/mL, respectively. This is the first report on the antimicrobial activity of stilbenes and oligostilbenes isolated from the leaf and stem of V. amurensis. Thus, this result suggests that natural antimicrobial compounds derived from V. amurensis may benefit oral health as plaque-control agents for the prevention of dental caries and periodontal disease. (C) 2009 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/22895http://dx.doi.org/10.1016/j.bmcl.2009.12.020
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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