Dynamic changes in the cortico-subcortical network during early motor learning

Title
Dynamic changes in the cortico-subcortical network during early motor learning
Author(s)
장성호박지원[박지원]김연희[김연희]장원혁[장원혁]박창현[박창현]김성태[김성태]
Keywords
POSITRON-EMISSION-TOMOGRAPHY; TRANSCRANIAL MAGNETIC STIMULATION; BRAIN ACTIVATION; VISUOMOTOR SEQUENCE; FUNCTIONAL-ANATOMY; SKILL ACQUISITION; PREMOTOR CORTEX; FRONTAL LOBES; CEREBELLUM; MOVEMENT
Issue Date
201003
Publisher
IOS PRESS
Citation
NEUROREHABILITATION, v.26, no.2, pp.95 - 103
Abstract
Background: Failure of early motor learning due to damage in any brain area involved in this process may interfere with successful rehabilitation of such patients. Objective: We investigated the changes in activation of the motor network during sequential finger motor learning to delineate the characteristics of the cortico-subcortical network during motor skill learning. Methods: Twenty healthy, right-handed volunteers participated. Subjects were instructed to perform eight blocks of a sequential finger motor task while functional MRI (fMRI) was performed. Results: The participants had an improvement in performance over time from block 1 to block 4, indicating that successful learning had occurred, followed by a plateau from block 5 to the last block. On fMRI, activities of the contralateral primary sensorimotor cortex, the premotor cortex, the supplementary motor area, and the posterior parietal cortex gradually increased from block 1 to block 4 and then decreased from block 5 to the last. In contrast, activity of the ipsilateral cerebellum showed a linear increase spanning the last block with peak activation. The thalamus and basal ganglia showed unilateral or bilateral activities at the unique stage of motor learning. Conclusions: These findings delineated the characteristic plastic changes and different roles of the cortico-subcortical network during the early phase of motor learning and automatization.
URI
http://hdl.handle.net/YU.REPOSITORY/22806http://dx.doi.org/10.3233/NRE-2010-0540
ISSN
1053-8135
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의과대학 > 재활의학교실 > Articles
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