A Matched Case-Control Study of a Novel Acid-Pump Antagonist and Proton-Pump Inhibitor for the Treatment of latrogenic Ulcers Caused by Endoscopic Submucosal Dissection

Title
A Matched Case-Control Study of a Novel Acid-Pump Antagonist and Proton-Pump Inhibitor for the Treatment of latrogenic Ulcers Caused by Endoscopic Submucosal Dissection
Author(s)
장병익김용길[김용길]김태년
Keywords
GASTRIC-ULCER; OMEPRAZOLE; RATS; HYPERPLASIA; SECRETION; THERAPY; SUBUNIT; ATPASE; OXIDE; MICE
Issue Date
201003
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v.4, no.1, pp.25 - 30
Abstract
Background/Aims: Revaprazan, a novel acid-pump antagonist, and proton-pump inhibitors (PPIs) have pH-independent effects on ulcer healing. The addition of a PPI promotes the cell restitution rate as well as vessel regeneration and maturation for ulcer repair. Revaprazan is known to protect the mucosa by increasing the prostaglandin concentration. Methods: We reviewed the medical records of patients who underwent endoscopic submucosal dissection (ESD) for gastric neoplasia at Yeungnam University Hospital between January 2008 and May 2009. We conducted a matched case-control study to compare the healing rates effected by revaprazan and rabeprazole. Results: Each group consisted of 30 patients. The baseline characteristics did not differ significantly between the two groups. Stage S1 disease was observed in 97% and 100% of patients after 8 weeks of treatment in the revaprazan and rabeprazole groups, respectively. In the revaprazan group, only one patient had stage H2 disease: a 54-year-old man with a 5.5-cm lesion after ESD of the ulcer, type Ila early gastric cancer, and adenocarcinoma. No serious adverse effects occurred during the treatment period in either group. Conclusions: The safety and efficacy profiles of revaprazan and rabeprazole are similar for the treatment of ESD-induced ulcers. (Gut Liver 2010; 4:25-30)
URI
http://hdl.handle.net/YU.REPOSITORY/22800http://dx.doi.org/10.5009/gnl.2010.4.1.25
ISSN
1976-2283
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의과대학 > 내과학교실 > Articles
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