Novel Self-nanoemulsifying Drug Delivery System for Enhanced Solubility and Dissolution of Lutein

Title
Novel Self-nanoemulsifying Drug Delivery System for Enhanced Solubility and Dissolution of Lutein
Author(s)
유봉규유정희[유정희]스리니바산 샨무감[스리니바산 샨무감]프리텀 따파[프리텀 따파]이응석프라바가[프라바가]랜가라잔 바스카란[랜가라잔 바스카란]윤상권[윤상권]최한곤용철순한건[한건]
Keywords
IN-OIL MICROEMULSIONS; INTESTINAL-ABSORPTION; CATARACT-EXTRACTION; MACULAR PIGMENT; PARTICLE-SIZE; ORAL DELIVERY; CAROTENOIDS; ZEAXANTHIN; RISK; BIOAVAILABILITY
Issue Date
201003
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.33, no.3, pp.417 - 426
Abstract
Self-nanoemulsifying drug delivery system (SNEDDS) containing oil (Phosal 53 MCT), surfactant (Labrasol), and cosurfactant (Transcutol-HP or Lutrol-E400) was prepared to enhance solubility and dissolution of lutein. Ternary phase diagram of the SNEDDS was constructed to identify the self-emulsifying regions following which the percentage of oil, surfactant, and cosurfactant in the SNEDDS were optimized in terms of emulsification time and mean emulsion droplet size. The optimized SNEDDS consists of 25% oil, 60% surfactant, and 15% cosurfactant. When measured using USP XXIII dissolution apparatus II, the emulsification time of the SNEDDS prepared with Transcutol-HP as cosurfactant was less than 20 sec, and it was 20-30 sec in the SNEDDS prepared with Lutrol-E400. Mean emulsion droplet size was slightly smaller when Transcutol-HP was used as cosurfactant (80 +/- 6 nm), compared to when Lutrol-E400 was used (93 +/- 6 nm). Dissolution of lutein from the solid SNEDDS (physical mixture of the optimized SNEDDS and Aerosil 200) took place immediately (less than 5 min) in distilled water, and, once dissolved, no precipitation or aggregation of the drug were observed. In contrast, no drug was released from lutein powder or from the commercial product (Eyelac (R)) until 3 h of the study duration.
URI
http://hdl.handle.net/YU.REPOSITORY/22799http://dx.doi.org/10.1007/s12272-010-0311-5
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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