Hepatoprotective Effect of Pinoresinol on Carbon Tetrachloride-Induced Hepatic Damage in Mice

Title
Hepatoprotective Effect of Pinoresinol on Carbon Tetrachloride-Induced Hepatic Damage in Mice
Author(s)
이승호김동춘김효연[김효연]김준기[김준기]최준호[최준호]정주연[정주연]오우용[오우용]이희상김영식[김영식]강삼식[강삼식]이선미[이선미]
Keywords
ACUTE LIVER-INJURY; NITRIC-OXIDE; FORSYTHIA-KOREANA; MEDICINAL-PLANTS; OLIVE OIL; C-JUN; RATS; ROLES; GLUTATHIONE; ACTIVATION
Issue Date
201003
Publisher
JAPANESE PHARMACOLOGICAL SOC
Citation
JOURNAL OF PHARMACOLOGICAL SCIENCES, v.112, no.1, pp.105 - 112
Abstract
Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities. This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from Forsythiae Fructus, against carbon tetrachloride (CCl(4))-induced liver injury. Mice were treated intraperitoneally with vehicle or pinoresinol (25, 50, 100, and 200 mg/kg) 30 min before and 2 h after CCl(4) (20 mu l/kg) injection. In the vehicle-treated CCl(4) group, serum aminotransferase activities were significantly increased 24 h after CCl(4) injection, and these increases were attenuated by pinoresinol at all doses. Hepatic glutathione contents were significantly decreased and lipid peroxidation was increased after CCl(4) treatment. These changes were attenuated by 50 and 100 mg/kg of pinoresinol. The levels of protein and mRNA expression of inflammatory mediators, including tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclooxygenase-2, were significantly increased after CCl(4) injection; and these increases were attenuated by pinoresinol. Nuclear translocation of nuclear factor-kappa B (NF-kappa B) and phosphorylation of c-Jun, one of the components of activating protein 1 (AP-1), were inhibited by pinoresinol. Our results suggest that pinoresinol ameliorates CCl(4)-induced acute liver injury, and this protection is likely due to anti-oxidative activity and down-regulation of inflammatory mediators through inhibition of NF-kappa B and AP-1.
URI
http://hdl.handle.net/YU.REPOSITORY/22766http://dx.doi.org/10.1254/jphs.09234FP
ISSN
1347-8613
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약학대학 > 약학부 > Articles
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