Anti-infective Discorhabdins from a Deep-Water Alaskan Sponge of the Genus Latrunculia

Title
Anti-infective Discorhabdins from a Deep-Water Alaskan Sponge of the Genus Latrunculia
Author(s)
나민균Yuanqing Ding[Yuanqing Ding]Bin Wang[Bin Wang]Babu L. Tekwani[Babu L. Tekwani]Raymond F. Schinazi[Raymond F. Schinazi]Scott Franzblau[Scott Franzblau]Michelle Kelly[Michelle Kelly]Robert Stone[Robert Stone]Xing-Cong Li[Xing-Cong Li]Daneel Ferreira[Daneel Ferreira]Mark T. Hamann[Mark T. Hamann]
Keywords
ELECTRONIC CIRCULAR-DICHROISM; THEORETICAL CALCULATION; CYTOTOXIC ALKALOIDS; MARINE SPONGES; SPECTRA; PIGMENT
Issue Date
201003
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.73, no.3, pp.383 - 387
Abstract
Bioassay- and LC-MS-guided fractionation of a methanol extract from a new, deep-water Alaskan sponge species of the genus Latrunculia resulted in the isolation of two new, brominated pyrroloiminoquinones, dihydrodiscorhabdin 11 (1) and discorhabdin Y (2), along with six known pyrroloiminoquinone alkaloids, discorhabdins A (3), C (4), E (5), and L (6), dihydrodiscorhabdin C (7), and (lie benzene derivative 8. Compounds 3, 4, and 7 exhibited anti-HCV activity, antimalarial activity, and selective antimicrobial activity. Although compounds 3 and 7 displayed potent and selective ill vitro antiprotozoal activity, Plasmodium berghei-infected mice did not respond to these metabolites clue to their toxicity in vivo.
URI
http://hdl.handle.net/YU.REPOSITORY/22745http://dx.doi.org/10.1021/np900281r
ISSN
0163-3864
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약학대학 > 약학부 > Articles
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