A Prospective Multi-center Trial of Escherichia coli Extract for the Prophylactic Treatment of Patients with Chronically Recurrent Cystitis

Title
A Prospective Multi-center Trial of Escherichia coli Extract for the Prophylactic Treatment of Patients with Chronically Recurrent Cystitis
Author(s)
정희창김건석[김건석]김지윤[김지윤]정인갑[정인갑]백재승[백재승]손환철[손환철]임대정[임대정]심홍방[심홍방]박원희[박원희]주명수[주명수]
Keywords
URINARY-TRACT-INFECTIONS; UNTREATED ASYMPTOMATIC BACTERIURIA; IMMUNE-RESPONSE; OM-89; IMMUNOTHERAPY; STIMULATION; PREVENTION; RESISTANCE; GIRLS; VAXOM
Issue Date
201003
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.3, pp.435 - 439
Abstract
We have assessed the efficacy and safety of Escherichia coli extract (ECE; UroVaxom (R)) which contains active immunostimulating fractions, in the prophylactic treatment of chronically recurrent cystitis. Forty-two patients with more than 2 episodes of cystitis in the proceeding 6 months were treated for 3 months with one capsule daily of ECE and observed for a further 6 months. The primary efficacy criterion was the number of episodes of recurrent cystitis during the 6 months after treatment compared to those during the 6 months before treatment. At the end of the 9-month trial, 34 patients (all women) were eligible for statistical analysis. Their mean age was 56.4 yr (range, 34-75 yr), and they had experienced recurrent urinary tract infections for 7.2 +/- 5.2 yr. The number of recurrences was significantly lower during the 6-month follow-up period than during the 6 months preceding the trial (0.35 vs. 4.26, P<0.001). During the follow-up, 28 (82.4%) patients had no recurrences and 4 (11.8%) had 1 each. In patients who relapsed, ECE alleviated cystitis symptoms, including painful voiding, frequency and urgency. There were no serious adverse events related to the study drug. Our study demonstrates the efficacy and safety of ECE in the prophylactic treatment of chronically recurrent cystitis.
URI
http://hdl.handle.net/YU.REPOSITORY/22739http://dx.doi.org/10.3346/jkms.2010.25.3.435
ISSN
1011-8934
Appears in Collections:
의과대학 > 비뇨기과학교실 > Articles
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