Comparative study of low doses of rosuvastatin and atorvastatin on lipid and glycemic control in patients with metabolic syndrome and hypercholesterolemia

Title
Comparative study of low doses of rosuvastatin and atorvastatin on lipid and glycemic control in patients with metabolic syndrome and hypercholesterolemia
Author(s)
박종선김영조최지용[최지용]김윤년[김윤년]홍택종[홍택종]김동수[김동수]김기영[김기영]정명호[정명호]채재건[채재건]오석규[오석규]성인환[성인환]
Keywords
apolipoprotein B; atorvastatin; cholesterol; glucose; high density lipoprotein cholesterol; insulin; lipid; low density lipoprotein cholesterol; rosuvastatin; adult; alanine aminotransferase blood level; article; bedtime dosage; cholesterol blood level; clinical trial; comparative study; controlled clinical trial; dizziness; drug safety; drug tolerability; edema; female; glucose blood level; glucose homeostasis; glycemic control; human; hypercholesterolemia; insulin blood level; insulin resistance; lipid analysis; lipoprotein blood level; low drug dose; major clinical study; male; metabolic parameters; metabolic syndrome X; multicenter study; myalgia; randomized controlled trial; side effect; treatment withdrawal; unspecified side effect; Blood Glucose; Cholesterol, LDL; Female; Fluorobenzenes; Hemoglobin A, Glycosylated; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperglycemia; Insulin; Male; Metabolic Syndrome X; Middle Aged; Pyrimidines; Pyrroles; Sulfonamides; Treatment Outcome
Issue Date
201003
Citation
Korean Journal of Internal Medicine, v.25, no.1, pp.27 - 35
Abstract
Background/Aims: This multicenter, open-labeled, randomized trial was performed to compare the effects of rosuvastatin 10 mg and atorvastatin 10 mg on lipid and glycemic control in Korean patients with nondiabetic metabolic syndrome. Methods: In total, 351 patients who met the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria for metabolic syndrome with low-density lipoprotein cholesterol (LDL-C) levels �� 130 mg/dL were randomized to receive either rosuvastatin 10 mg (n = 173) or atorvastatin 10 mg (n = 178) for over 6 weeks. Results: After 6 weeks of treatment, greater reductions in total cholesterol (- 35.94 �� 11.38 vs. - 30.07 �� 10.46%, p < 0.001), LDL-C (48.04 �� 14.45 vs. 39.52 �� 14.42%, p < 0.001), non-high-density lipoprotein cholesterol (- 42.93 �� 13.15 vs. - 35.52 �� 11.76%, p < 0.001), and apolipoprotein-B (- 38.7 �� 18.85 vs. - 32.57 �� 17.56%, p = 0.002) levels were observed in the rosuvastatin group as compared to the atorvastatin group. Overall, the percentage of patients attaining the NCEP ATP III goal was higher with rosuvastatin as compared to atorvastatin (87.64 vs. 69.88%, p < 0.001). Changes in glucose and insulin levels, and homeostasis model assessment of insulin resistance index were not significantly different between the two groups. The safety and tolerability of the two agents were similar. Conclusions: Rosuvastatin 10 mg was more effective than atorvastatin 10 mg in achieving NCEP ATP III LDL-C goals in patients with nondiabetic metabolic syndrome, especially in those with lower NCEP ATP III target level goals.
URI
http://hdl.handle.net/YU.REPOSITORY/22737http://dx.doi.org/10.3904/kjim.2010.25.1.27
ISSN
1226-3303
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의과대학 > 내과학교실 > Articles
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