신장 이식 후 재발한 국소성 분절성 사구체 경화증 치료로 사용한 Rituximab과 혈장교환술 plasmapheresis 1예

Title
신장 이식 후 재발한 국소성 분절성 사구체 경화증 치료로 사용한 Rituximab과 혈장교환술 plasmapheresis 1예
Other Titles
Rituximab and Plasmapheresis for Post-transplant Recurrence of FSGS
Author(s)
남주연[남주연]최안숙[최안숙]김수진[김수진]지병훈[지병훈]오준석[오준석]손영기[손영기]신용훈[신용훈]김중경[김중경]김용진
Keywords
Focal segmental glomerulosclerosis; Rituximab; Kidney transplantation; Focal segmental glomerulosclerosis; Rituximab; Kidney transplantation
Issue Date
201003
Publisher
대한신장학회
Citation
Kidney Research and Clinical Practice, v.29, no.2, pp.292 - 295
Abstract
Focal segmental glomerular sclerosis (FSGS) is known to recur in 20-40% of the renal allografts with graft loss in about half of these cases. We report a successful treatment of a recurrent FSGS after kidney transplantation with rituximab and plasmapheresis. An 16-year-old patient whose primary kidney disease was FSGS developed recurrence of proteinuria after living donor kidney transplantation despite preemptive plasmapheresis and one dose of rituximab (375 mg/m2). After kidney transplantation, nephrotic range proteinuria was detected. Kidney biopsy was done and showed recurrent FSGS. She undergone 11 times of plasmapheresis in the first 4 week post transplantation. In addition, she received additional one dose of rituximab (375 mg/m2) on day 14. Proteinuria was decreased below nephrotic range at 37 day. Ten months later, proteinuria was at 30 mg/day with excellent graft function. No significant adverse events related to rituximab or plasmapheresis were observed. Rituximab with plasmapheresis may be another option for recurrent FSGS after kidney transplantation.
URI
http://hdl.handle.net/YU.REPOSITORY/22710
ISSN
2211-9132
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의과대학 > 병리학교실 > Articles
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