Regulation of Selenoproteins and Methionine Sulfoxide Reductases A and B1 by Age, Calorie Restriction, and Dietary Selenium in Mice

Title
Regulation of Selenoproteins and Methionine Sulfoxide Reductases A and B1 by Age, Calorie Restriction, and Dietary Selenium in Mice
Author(s)
김화영Novoselov SV[Novoselov SV]Hua D[Hua D]Lee BC[Lee BC]Astle CM[Astle CM]Harrison DE[Harrison DE]Friguet B[Friguet B]Moustafa ME[Moustafa ME]Carlson BA[Carlson BA]Hatfield DL[Hatfield DL]Gladyshev VN[Gladyshev VN]
Keywords
GLUTATHIONE-PEROXIDASE; LIFE-SPAN; SELENOCYSTEINE INSERTION; ANTIOXIDANT DEFENSE; OXIDATIVE STRESS; GENE-EXPRESSION; TRANSGENIC MICE; PROTEIN; MITOCHONDRIAL; RATS
Issue Date
201004
Publisher
MARY ANN LIEBERT INC
Citation
ANTIOXIDANTS & REDOX SIGNALING, v.12, no.7, pp.829 - 838
Abstract
Methionine residues are susceptible to oxidation, but this damage may be reversed by methionine sulfoxide reductases MsrA and MsrB. Mammals contain one MsrA and three MsrBs, including a selenoprotein MsrB1. Here, we show that MsrB1 is the major methionine sulfoxide reductase in liver of mice and it is among the proteins that are most easily regulated by dietary selenium. MsrB1, but not MsrA activities, were reduced with age, and the selenium regulation of MsrB1 was preserved in the aging liver, suggesting that MsrB1 could account for the impaired methionine sulfoxide reduction in aging animals. We also examined regulation of Msr and selenoprotein expression by a combination of dietary selenium and calorie restriction and found that, under calorie restriction conditions, selenium regulation was preserved. In addition, mice overexpressing a mutant form of selenocysteine tRNA reduced MsrB1 activity to the level observed in selenium deficiency, whereas MsrA activity was elevated in these animals. Finally, we show that selenium regulation in inbred mouse strains is preserved in an outbred aging model. Taken together, these findings better define dietary regulation of methionine sulfoxide reduction and selenoprotein expression in mice with regard to age, calorie restriction, dietary Se, and a combination of these factors. Antioxid. Redox Signal. 12, 829-838.
URI
http://hdl.handle.net/YU.REPOSITORY/22639http://dx.doi.org/10.1089/ars.2009.2895
ISSN
1523-0864
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의과대학 > 생화학.분자생물학교실 > Articles
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