Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms A Multicenter Study in Korea

Title
Ischemic Stroke in Cancer Patients With and Without Conventional Mechanisms A Multicenter Study in Korea
Author(s)
이준Seon Gyeong Kim[Seon Gyeong Kim]Ji Man Hong[Ji Man Hong]Hahn Young Kim[Hahn Young Kim]Pil-Wook Chung[Pil-Wook Chung]Kwang-Yeol Park[Kwang-Yeol Park]Gyeong-Moon Kim[Gyeong-Moon Kim]Kwang Ho Lee[Kwang Ho Lee]Chin-Sang Chung[Chin-Sang Chung]Oh Young Bang[Oh Young Bang]
Keywords
CEREBROVASCULAR COMPLICATIONS; RISK-FACTOR; MANIFESTATION; ETIOLOGY; PATTERN
Issue Date
201004
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
STROKE, v.41, no.4, pp.798 - 801
Abstract
Background and Methods-To assess the precise mechanisms of stroke in cancer patients, we analyzed the data for cancer patients with acute ischemic stroke registered from 6 centers in South Korea. Clinical features, risk factors, diffusion-weighted imaging lesion patterns, and laboratory findings including D-dimer levels were compared between patients with conventional stroke mechanisms (CSMs) and cryptogenic group. Results-A total of 161 patients were included in this study: 97 (60.2%) patients in the CSM group and 64 (39.8%) in the cryptogenic group. Patients in the CSM group were older and vascular risk factors were more prevalent than in the cryptogenic group. Diffusion-weighted imaging patterns of multiple lesions involving multiple arterial territories were observed more frequently in the cryptogenic group than in the CSM group. In addition, levels of the D-dimer were higher in the cryptogenic group than in the CSM group (11.5 +/- 14.6 versus 3.6 +/- 10.3 mu g/dL). In multivariate analysis, the diffusion-weighted imaging lesion pattern of multiple vascular territories (odds ratio, 11.2; 95% CI, 3.74 to 33.3), and D-dimer levels of >1.11 mu g/dL (odds ratio, 10.6; 95% CI, 3.29 to 33.8) were associated independently with the cryptogenic group. Conclusions-Stroke outside of CSM occurred in a large number in cancer patients. In stroke patients with cancer, D-dimer levels and diffusion-weighted imaging lesion patterns may be helpful in early identification of non-CSMs (especially coagulopathy associated with cancer) and possibly in guiding preventive strategies for stroke. (Stroke. 2010; 41: 798-801.)
URI
http://hdl.handle.net/YU.REPOSITORY/22636http://dx.doi.org/10.1161/STROKEAHA.109.571356
ISSN
0039-2499
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의과대학 > 신경과학교실 > Articles
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