Polymeric Micelles with Ionic Cores Containing Biodegradable Cross-Links for Delivery of Chemotherapeutic Agents

Title
Polymeric Micelles with Ionic Cores Containing Biodegradable Cross-Links for Delivery of Chemotherapeutic Agents
Author(s)
김종오거랍 사하이[거랍 사하이]알렉산더 카바노프[알렉산더 카바노프]타티아나 브로니치[타티아나 브로니치]
Keywords
DRUG-DELIVERY; MEDIATED ENDOCYTOSIS; COPOLYMER MICELLES; IN-VIVO; NANOGELS; ACID); NANOCARRIERS; POLYPLEXES; TRANSPORT; CARRIERS
Issue Date
201004
Publisher
AMER CHEMICAL SOC
Citation
BIOMACROMOLECULES, v.11, no.4, pp.919 - 926
Abstract
Novel functional polymeric nanocarriers with ionic cores containing biodegradable cross-links were developed for delivery of chemotherapeutic agents. Block ionomer complexes (BIC) of poly(ethylene oxide)-b-poly(methacylic acid) (PEO-b-PMA) and divalent metal cations (Ca(2+)) were utilized as templates. Disulfide bonds were introduced into the ionic cores by using cystamine as a biodegradable cross-linker. The resulting cross-linked micelles with disulfide bonds represented soft, hydrogel-like nanospheres and demonstrated a time-dependent degradation in the conditions mimicking the intracellular reducing environment. The ionic character of the cores allowed to achieve a very high level of doxorubicin (DOX) loading (50% w/w) into the cross-linked micelles. DOX-loaded degradable cross-linked micelles exhibited more potent cytotoxicity against human A2780 ovarian carcinoma cells as compared to micellar formulations without disulfide linkages. These novel biodegradable cross-linked micelles are expected to be attractive candidates for delivery of anticancer drugs.
URI
http://hdl.handle.net/YU.REPOSITORY/22624http://dx.doi.org/10.1021/bm9013364
ISSN
1525-7797
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약학대학 > 약학부 > Articles
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