Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity

Title
Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity
Author(s)
나민균Tran Manh Hung[Tran Manh Hung]Cao Van Thu[Cao Van Thu]Nguyen Tien Dat[Nguyen Tien Dat]류승우[류승우]이정형[이정형]김진철[김진철]정현주[정현주]배기환[배기환]민병선[민병선]
Keywords
CONSTITUENTS; EOTAXIN; TUBER; EOSINOPHIL; GLYCOSIDES; CELLS; RECRUITMENT; EXPRESSION; EXTRACT
Issue Date
201004
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.20, no.8, pp.2412 - 2416
Abstract
Three new homoiso. avonoids (1-3) were isolated from the roots of Ophiopogon japonicus (Liliaceae). The structures of new metabolites were determined on the basis of spectroscopic analyses including 2D NMR. The anti-inflammatory activities of new compounds (1-3) were investigated by their effects on the release of the inflammatory chemokine eotaxin, stimulated by IL-4 and the combination of IL-4 and TNF-alpha in BEAS-2B cells, which mimics the in vivo conditions in bronchial allergic asthma. (C) 2010 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/22607http://dx.doi.org/10.1016/j.bmcl.2010.03.043
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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