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dc.contributor.author이종순ko
dc.contributor.author이세영[이세영]ko
dc.contributor.authorGerd P. Pfeifer[Gerd P. Pfeifer]ko
dc.date.accessioned2015-12-17T00:04:12Z-
dc.date.available2015-12-17T00:04:12Z-
dc.date.created2015-11-13-
dc.date.issued201004-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v.33, no.4, pp.633 - 636-
dc.identifier.issn0253-6269-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/22599-
dc.identifier.urihttp://dx.doi.org/10.1007/s12272-010-0419-7-
dc.description.abstractAdozelesin is a synthetic analog of the antitumor antibiotic, CC-1065, which alkylates N3 of adenine in the minor DNA groove in a sequence-specific manner. Here we tested the mutation spectra induced by adozelesin in the supF gene of human XP-A fibroblasts using a shuttle vector assay. Adozelesin primarily induces mutations via an A -> T transversion and a single base insertion. The A -> T transversion (43/59) was observed at the adenine alkylation site in the 5'-ATTTA* sequence (A* is the site of alkylation). The single base insertion (5/59) was observed at the 3'-side of the covalently modified adenine in the 5'-CTAAA* sequence. The results of this study suggest that the DNA alkylating sequence of adozelesin influences the type of DNA mutation.-
dc.language영어-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.subjectANTITUMOR ANTIBIOTIC CC-1065-
dc.subjectDNA-SEQUENCE SPECIFICITY-
dc.subjectESCHERICHIA-COLI-
dc.subjectMAMMALIAN-CELLS-
dc.subjectSHUTTLE VECTOR-
dc.subjectADDUCT-
dc.subjectPOLYMERASE-
dc.subjectINVITRO-
dc.subjectALKYLATION-
dc.subjectNSC-298223-
dc.titleMutation Spectra Induced by Adozelesin in the supF Gene of Human XP-A Fibroblasts-
dc.typeArticle-
dc.identifier.wosid000276970700020-
dc.identifier.scopusid2-s2.0-77954493522-
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