Comparison of the Binding Modes of [Ru(2,2 '-bipyridine)(3)](2+) and [Ru(2,2 ':6 ',2 ''-terpyridine)(2)](2+) to Native DNA

Title
Comparison of the Binding Modes of [Ru(2,2 '-bipyridine)(3)](2+) and [Ru(2,2 ':6 ',2 ''-terpyridine)(2)](2+) to Native DNA
Author(s)
장윤정이현미장경주[장경주]이재철[이재철]김석규조태섭
Keywords
LINEAR DICHROISM SPECTROSCOPY; RUTHENIUM(II) COMPLEXES; ANCILLARY LIGANDS; MINOR-GROOVE; ACID-BASE; INTERCALATION; BEHAVIORS; SOLVENT; PROBE; GEOMETRIES
Issue Date
201005
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.31, no.5, pp.1314 - 1318
Abstract
The [Ru(tpy)(2)]Cl-2 (tpy:2,2':6',2 ''-terpyridine) complex was synthesized and its structure was confirmed by H-1-NMR and elemental analysis. Its binding mode toward DNA was compared with the well-known [Ru(bpy)(3)]Cl-2 (bpy:2,2-bipyridyl), using isotropic absorption, linear dichroism(LD) spectroscopy, and an energy minimization study. Compared to [Ru (bpy)(3)](2+), the [Ru(tpy)(2)](2+) complex exhibited very little change in its absorption pattern, especially in the MLCT band, upon binding to DNA. Furthermore, upon DNA binding, both Ru(II) complexes induced a decrease in the LD magnitude in the DNA absorption region. The [Ru(tpy)(2)](2+) complex produced a strong positive LD signal in the ligand absorption region, which is in contrast with the [Ru(bpy)(3)](2+) complex. Observed spectral properties led to the conclusion that the interaction between the ligands and DNA bases is negligible for the [Ru(tpy)(3)](2+) complex, although it formed an adduct with DNA. This conclusion implies that both complexes bind to the surface of DNA, most likely to negatively charged phosphate groups via a simple electrostatic interaction, thereby orienting to exhibit the LD signal. The energy minimization calculation also supported this conclusion.
URI
http://hdl.handle.net/YU.REPOSITORY/22480http://dx.doi.org/10.5012/bkcs.2010.31.5.1314
ISSN
0253-2964
Appears in Collections:
문과대학 > 중국언어문화학과 > Articles
이과대학 > 화학생화학부 > Articles
교육대학원 > 교육대학원 > Articles
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