Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells

Title
Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells
Author(s)
Yo Omata[Yo Omata]Yoshiro Saito[Yoshiro Saito]Yasukazu Yoshida[Yasukazu Yoshida]정병선Remigiusz Serwa[Remigiusz Serwa]Tae-gyu Nam[Tae-gyu Nam]Ned Porter[Ned Porter]Etsuo Niki[Etsuo Niki]
Keywords
LOW-DENSITY-LIPOPROTEIN; CHAIN-BREAKING ANTIOXIDANTS; VITAMIN-E; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; HYDROGEN-PEROXIDE; CELLULAR UPTAKE; PC12 CELLS; INHIBITION; MEMBRANES
Issue Date
201005
Publisher
ELSEVIER SCIENCE INC
Citation
FREE RADICAL BIOLOGY AND MEDICINE, v.48, no.10, pp.1358 - 1365
Abstract
Free radical-mediated lipid peroxidation has been implicated in the pathogenesis of various diseases. Lipid peroxidation products are cytotoxic and they modify proteins and DNA bases, leading eventually to degenerative disorders. Various synthetic antioxidants have been developed and assessed for their capacity to inhibit lipid peroxidation and oxidative stress induced by free radicals. In this study, the capacity of novel 6-amino-2,4,5-trimethyl-3-pyridinols for scavenging peroxyl radicals, inhibiting plasma lipid peroxidation in vitro, and preventing cytotoxicity induced by glutamate, 6-hydroxydopamine, 1-methyl-4-phenylpyridium (MPP(+)), and hydroperoxyoctadecadienoic acid was assessed. It was found that they exerted higher reactivity toward peroxyl radicals and more potent activity for inhibiting the above oxidative stress than alpha-tocopherol, the most potent natural antioxidant, except against the cytotoxicity induced by MPP(+). These results suggest that the novel 6-amino-3-pyridinols may be potent antioxidants against oxidative stress. (C) 2010 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/22478http://dx.doi.org/10.1016/j.freeradbiomed.2010.02.018
ISSN
0891-5849
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약학대학 > 약학부 > Articles
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