Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

Title
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
Author(s)
라다깔끼[라다깔끼]프리텀다빠[프리텀다빠]강미정정태천남정민[남정민]김혜린[김혜린]나영화[나영화]조원제[조원제]권영주[권영주]이응석
Keywords
DNA TOPOISOMERASES; CANCER CELLS; DERIVATIVES; COMPLEXES; COVALENT; AGENTS
Issue Date
201005
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY, v.18, no.9, pp.3066 - 3077
Abstract
A new series of 2,4-diphenyl-6-aryl pyridines containing hydroxyl group(s) at the ortho, meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase I and II inhibitory activity and cytotoxicity against several human cancer cell lines for the development of novel anticancer agents. Structure-activity relationship study revealed that the substitution of hydroxyl group( s) increased topoisomerase I and II inhibitory activity in the order of meta > para > ortho position. Substitution of hydroxyl group on the para position showed better cytotoxicity. (c) 2010 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/22477http://dx.doi.org/10.1016/j.bmc.2010.03.051
ISSN
0968-0896
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약학대학 > 약학부 > Articles
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