Senescence-Related Truncation and Multimerization of Apolipoprotein A-I in High-Density Lipoprotein With an Elevated Level of Advanced Glycated End Products and Cholesteryl Ester Transfer Activity

Title
Senescence-Related Truncation and Multimerization of Apolipoprotein A-I in High-Density Lipoprotein With an Elevated Level of Advanced Glycated End Products and Cholesteryl Ester Transfer Activity
Author(s)
조경현박기훈[박기훈]신동구김재룡
Keywords
CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; TRANSFER PROTEIN; HUMAN-SERUM; LIPID-FREE; SIZE; AGE; FRUCTOSE; PLASMA
Issue Date
201005
Publisher
OXFORD UNIV PRESS INC
Citation
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v.65, no.6, pp.600 - 610
Abstract
To compare the change in lipoprotein metabolism with aging, we analyzed the lipid and protein compositions of individual lipoprotein fractions. Healthy and nonobese elderly participants (elderly group, n = 26) had a serum lipid profile within the normal range, although slightly higher than in young participants (control group, n = 18). However, the elderly group had a twofold higher serum uric acid level and triglyceride (TG):high-density lipoprotein cholesterol ratio. The elderly group had less antioxidant ability and elevated TG content in high-density lipoprotein (HDL) with enhanced cholesteryl ester transfer activity. An elevated level of advanced glycated end products in lipoproteins and fragmentation of apoA-I were present in the elderly group, with detected lower apoA-I level and more multimerized apoA-I in HDL. The protein levels of apoA-I, apoC-III, and serum amyloid A in lipoprotein-deficient serum were increased in the elderly group.
URI
http://hdl.handle.net/YU.REPOSITORY/22475http://dx.doi.org/10.1093/gerona/glq034
ISSN
1079-5006
Appears in Collections:
생명공학부 > 생명공학부 > Articles
의과대학 > 내과학교실 > Articles
의과대학 > 생화학.분자생물학교실 > Articles
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