Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer: a Korean Cancer Study Group phase II trial

Title
Gemcitabine and oxaliplatin in patients with unresectable biliary cancer including gall bladder cancer: a Korean Cancer Study Group phase II trial
Author(s)
이경희장정순[장정순]임호영[임호영]황인규[황인규]송홍숙[송홍숙]유내춘[유내춘]윤소영[윤소영]김열홍[김열홍]박은식[박은식]변재호[변재호]이명아[이명아]오숙중[오숙중]김봉석[김봉석]오상철[오상철]김삼용[김삼용]이상재[이상재]
Keywords
TRACT CARCINOMA; CHEMOTHERAPY; GALLBLADDER; CISPLATIN; CHOLANGIOCARCINOMA; EXPERIENCE
Issue Date
201005
Publisher
SPRINGER
Citation
CANCER CHEMOTHERAPY AND PHARMACOLOGY, v.65, no.4, pp.641 - 647
Abstract
Chemotherapy represents a palliative treatment, with poor response rates and a median survival of less than 6 months in patients with biliary tract cancers (BTCs). The aim of this study was to evaluate the efficacy and safety of the combination chemotherapy with gemcitabine and oxaliplatin (GEMOX) in patients with BTCs including gall bladder cancer. We carried out a nationwide multicenter phase II study evaluated the efficacy and safety of GEMOX as first-line therapy in patients with advanced BTCs. Eligible patients with previously untreated locally advanced or metastatic BTCs received gemcitabine 1,000 mg/m(2) (day 1 and 8) and oxaliplatin 100 mg/m(2) (day 1), every 3 weeks. Fifty-three patients were evaluated, 60% had cholangiocarcinoma and the remaining 40% gall bladder cancer; the objective response rate was 18.9% (10/53 patients including 1 Complete response) [14.9%; 95% confidence interval (CI), 7.4-25.7%] in the treated population. Stable disease were observed in 27/53 (50.9%) patients, disease control rate was achieved in 69.8% of all patients. Median progression-free survival was 4.8 months (3.1-6.5, 95% CI) and median overall survival was 8.3 months (5.8-10.8, 95% CI). Grade 3/4 toxicities included neutropenia (33.9% of patients) and thrombocytopenia (7.6%). The GEMOX regimen demonstrated a modest antitumor activity and is well tolerated in patients with advanced BTCs.
URI
http://hdl.handle.net/YU.REPOSITORY/22450http://dx.doi.org/10.1007/s00280-009-1069-7
ISSN
0344-5704
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의과대학 > 내과학교실 > Articles
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