Cutaneous Alternaria infectoria infection in a dog in association with therapeutic immunosuppression for the management of immune-mediated haemolytic anaemia

Title
Cutaneous Alternaria infectoria infection in a dog in association with therapeutic immunosuppression for the management of immune-mediated haemolytic anaemia
Author(s)
최종수Dedola, Carla[Dedola, Carla]Stuart, Alasdair P. G.[Stuart, Alasdair P. G.]Ridyard, Alison E.[Ridyard, Alison E.]Else, Roderick W.[Else, Roderick W.]van den Broek, Adri H. M.[van den Broek, Adri H. M.]de Hoog, G. Sybren[de Hoog, G. Sybren]Thoday, Keith L.[Thoday, Keith L.]
Keywords
ITRACONAZOLE TREATMENT; TRANSPLANT RECIPIENT; FUNGAL FLORA; PHEOHYPHOMYCOSIS; CATS; SUSCEPTIBILITY; CIPROFLOXACIN; DIAGNOSIS; TAXONOMY; MYCOSIS
Issue Date
201005
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Citation
VETERINARY DERMATOLOGY, v.21, no.6, pp.626 - 634
Abstract
A 4-year-old, ovariohysterectomized, English springer spaniel on immunosuppressive therapy was re-examined for the review of its immune-mediated haemolytic anaemia and the recent development of skin lesions. For the 3 months since hospital discharge, the dog had been receiving 1.3 mg/kg prednisolone and 2.6 mg/kg ciclosporin, both administered orally twice daily. Physical examination revealed hepatomegaly and multiple, purulent, crusting, erosive to ulcerative lesions over different body areas. Onychorrhexis had occurred on one digit and the underlying corium had blackened. There were two proliferative and one plaque-like lesions in the mouth. Thick walled fungal hyphae were detected in impression smears from all skin lesions and staining with periodic acid-Schiff's stain confirmed the presence of multiple fungal hyphae and spores in all biopsies examined. Fungal culture isolated a heavy, pure growth of an Alternaria sp. which was identified as A. infectoria by sequencing the internal transcribed spacer 1 region of the rRNA gene. The animal's condition prevented detailed investigation of the oral lesions. Withdrawal of the ciclosporin and reduction of the prednisolone dosage resulted in spontaneous resolution of the skin lesions within 40 days. Further gradual decrements in the prednisolone dosage to zero were carried out without recurrence of the immune-mediated haemolytic anaemia. After 12 months, there has been no recurrence of either the skin lesions or the anaemia. To the authors' knowledge, this is the first reported case of A. infectoria infection in a dog.
URI
http://hdl.handle.net/YU.REPOSITORY/22441http://dx.doi.org/10.1111/j.1365-3164.2009.00875.x
ISSN
0959-4493
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의과대학 > 피부과학교실 > Articles
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