Current Trends in the Epidemiological and Pathological Characteristics of Gastrointestinal Stromal Tumors in Korea, 2003-2004

Title
Current Trends in the Epidemiological and Pathological Characteristics of Gastrointestinal Stromal Tumors in Korea, 2003-2004
Author(s)
배영경손진희[손진희]조미연[조미연]김준미[김준미]김경미[김경미]박영수[박영수]김우호[김우호]정진숙[정진숙]정은선[정은선]진소영[진소영]
Keywords
DIFFERENTIAL-DIAGNOSIS; RISK STRATIFICATION; NORTHERN NORWAY; DIFFERENT SITES; KIT; POPULATION; MUTATIONS; PROGNOSIS; MALIGNANCY; MANAGEMENT
Issue Date
201006
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.25, no.6, pp.853 - 862
Abstract
Despite remarkable progress in understanding and treating gastrointestinal stromal tumors (GISTs) during the past two decades, the pathological characteristics of GISTs have not been made clear yet. Furthermore, concrete diagnostic criteria of malignant GISTs are still uncertain. We collected pathology reports of 1,227 GISTs from 38 hospitals in Korea between 2003 and 2004 and evaluated the efficacy of the NIH and AFIP classification schemes as well as the prognostic factors among pathologic findings. The incidence of GISTs in Korea is about 1.6 to 2.2 patients per 100,000. Extra-gastrointestinal GISTs (10.1%) are more common in Korea than in Western countries. In univariate analysis, gender, age, tumor location, size, mitosis, tumor necrosis, vascular and mucosal invasions, histologic type, CD34 and s-100 protein expression, and classifications by the NIH and AFIP criteria were found to be significantly correlated with patient's survival. However, the primary tumor location, stage and classification of the AFIP criteria were prognostically significant in predicting patient's survival in multivariate analysis. The GIST classification based on original tumor location, size, and mitosis is more efficient than the NIH criteria in predicting patient's survival, but the mechanism still needs to be clarified through future studies.
URI
http://hdl.handle.net/YU.REPOSITORY/22396http://dx.doi.org/10.3346/jkms.2010.25.6.853
ISSN
1011-8934
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의과대학 > 병리학교실 > Articles
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