Clinical and Angiographic Outcomes of Drug-Eluting Stents in Patients With Large Vessel and Single Coronary Artery Lesion

Title
Clinical and Angiographic Outcomes of Drug-Eluting Stents in Patients With Large Vessel and Single Coronary Artery Lesion
Author(s)
박종선김영조신동구홍그루이상희김웅[김웅]김동기[김동기]설상훈[설상훈]양태현[양태현]김대경[김대경]김두일[김두일]김동수[김동수]김동기[김동기]조윤경[조윤경]김형섭[김형섭]남창욱[남창욱]허승호[허승호]김권배[김권배]
Keywords
BARE METAL STENTS; RESTENOSIS; TRIAL; REVASCULARIZATION; PLACEMENT; DISEASE; SIZE
Issue Date
201006
Publisher
JOHN WILEY & SONS INC
Citation
CLINICAL CARDIOLOGY, v.33, no.6, pp.340 - 344
Abstract
Background: The aim of this study was to evaluate and compare the clinical and angiographic outcomes of 3 drug-eluting stents (DES) in patients with large vessel diameter and single coronary artery lesions. Hypothesis: The efficacy of 3 DESs may be similar. Methods: A total of 411 consecutive patients who visited 3 university hospitals from June 2004 to December 2007 and had a single coronary lesion which was treated with the use of a DES that was 3.5 mm in diameter were enrolled in this study. Patients were divided into 3 stent groups: Paclitaxel-eluting stent (PES, n = 105), Sirolimus-eluting stent (SES, n = 259), and Zotarolimus-eluting stent (ZES, n = 47). The study end point was a composite of major adverse cardiac events (MACE) including cardiac death, myocardial infarction (MI), and ischemia-driven target-vessel revascularization (TVR) for 12 months. Results: Baseline characteristics were not different. Late loss was higher in the ZES group than the other stents (0.5 +/- 0.4 mm in SES vs 0.3 +/- 0.5 mm in PES, 0.7 +/- 0.5 mm in ZES, P = 0.001). The total MACE-free survival rate was not significantly different between the SES group and the PES group (98.8% in SES vs 97.1% in PES, P = 0.252) or the PES group and the ZES group (97.1% in PES vs 93.6% in ZES, P = 0.301). However, the SES group showed a significantly better MACE-free survival rate compared with the ZES group (98.8% in SES vs 93.6% in ZES, P = 0.018). Conclusions: Clinical and angiographic outcomes of DES in a large vessel diameter and single coronary artery is excellent and SES appears to show better angiographic and clinical outcomes than ZES.
URI
http://hdl.handle.net/YU.REPOSITORY/22381http://dx.doi.org/10.1002/clc.20744
ISSN
0160-9289
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의과대학 > 내과학교실 > Articles
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