Impaired Cation Transport May Lead to Bioelectrical Impedance Changes during Hepatic Ischemia

Title
Impaired Cation Transport May Lead to Bioelectrical Impedance Changes during Hepatic Ischemia
Author(s)
윤성수이동식김홍진김종연최미란안현수[안현수]
Keywords
ELECTRICAL-IMPEDANCE; TISSUE; LIVER; MICRODIALYSIS; SPECTROSCOPY; ACCUMULATION; SENSITIVITY; OCCLUSION; SPACE; K+
Issue Date
201006
Publisher
KOREAN SURGICAL SOCIETY
Citation
JOURNAL OF THE KOREAN SURGICAL SOCIETY, v.78, no.6, pp.390 - 397
Abstract
Purpose: Ischemia and reperfusion (I/R) injury is a major cause of hepatic failure after liver surgery, but there is no direct method to monitor it in real-time (like an electrocardiogram in heart disease) during surgery. Recently we found the possible role of bioelectrical. impedance (BET) to monitor I/R injury in liver. But the mechanism responsible for ischemia-related BEI changes has not been clearly determined. Methods: The authors used an LCR meter to quantify BEI changes at 0.12 KHz. Livers were subjected to 70% partial ischemia for 120 minutes, and ATP contents, cation changes in extracellular fluid (ECF; determined using an in vivo intracellular microdialysis technique), hepatocyte sizes, and histological changes were then examined. Results: Liver tissue BEI was found to increase gradually during the first 60 minutes of ischemia and then tended to plateau. During the same period, intracellular ATP contents decreased to below 20% of the baseline level, [Na(+)] in ECF decreased from 150.4 +/- 3.8 to 97.8 +/- 10.6 mmol/L, and [K(+)] in ECF increased from 7.5 +/- 0.3 to 34.3 +/- 5.5 mmol/L during the first 60 minutes of ischemia. Hepatocyte diameter increased by 20% during the first 60 minutes of ischemia. Conclusion: This study suggests that BET changes during hepatic ischemia are probably caused by sodium and potassium concentration changes in the ECF due to reduced intracellular ATP contents. (J Korean Surg Soc 2010;78:390-397)
URI
http://hdl.handle.net/YU.REPOSITORY/22380http://dx.doi.org/10.4174/jkss.2010.78.6.390
ISSN
2233-7903
Appears in Collections:
의과대학 > 성형외과학교실 > Articles
의과대학 > 생리학교실 > Articles
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