Enantioseparation on cellulose dimethylphenylcarbamate-modified zirconia monolithic columns by reversed-phase capillary electrochromatography
- Enantioseparation on cellulose dimethylphenylcarbamate-modified zirconia monolithic columns by reversed-phase capillary electrochromatography
- 박정학; 프라빈쿠마르
- LIQUID-CHROMATOGRAPHIC RESOLUTION; CHIRAL PACKING MATERIALS; SILICA COLUMNS; ELECTROOSMOTIC FLOW; STATIONARY PHASES; CONTINUOUS BEDS; SEPARATION; PERFORMANCE; ENANTIOMERS; GEL
- Issue Date
- ELSEVIER SCIENCE BV
- JOURNAL OF CHROMATOGRAPHY A, v.1217, no.26, pp.4494 - 4500
- This work reports the preparation of monolithic zirconia chiral columns for separation of enantiomeric compounds by capillary electrochromatography (CEC). Using sal-gel technology, a porous monolith having interconnected globular-like structure with through-pores is synthesized in the capillary column as a first step in the synthesis of monolithic zirconia chiral capillary columns. In the second step, the surface of the monolith is modified by coating with cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) as the chiral stationary phase to obtain a chiral column (CDMPCZM). The process of the preparation of the zirconia monolithic capillary column was investigated by varying the concentrations of the components of the sal solution including polyethylene glycol, water and acetic acid. CDMPCZM is mechanically stable and no bubble formation was detected with the applied current of up to 30 mu A. The enantioseparation behavior of the CDMPCZM columns was investigated by separating a set of 10 representative chiral compounds by varying the applied voltage and pH and organic composition of the aqueous organic mobile phases. (C) 2010 Elsevier B.V. All rights reserved.
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