Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation

Title
Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf/MEK1/2/ERK 1/2 pathway activation
Author(s)
손종근배홍범[배홍범]이 명[이 명]서창섭[서창섭]장성현[장성현]김석재[김석재]정철원[정철원]이형곤[이형곤]김응모[김응모]박환철[박환철]곽상현[곽상현]
Keywords
NF-KAPPA-B; PROTEIN-KINASE-C; TNF-ALPHA; MACROPHAGE ACTIVATION; MOLECULAR-MECHANISMS; GENE-EXPRESSION; LIPOPOLYSACCHARIDE; SEPSIS; CELLS; RAS
Issue Date
201006
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL IMMUNOPHARMACOLOGY, v.10, no.9, pp.1022 - 1028
Abstract
We investigated the anti-inflammatory effects of sauchinone, a lignan isolated from Saururus chinensis, and the underlying mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. To assess the effects of sauchinone on LPS-induced macrophages activation, we measured the production of tumor necrosis factor (TNF)-alpha and macrophage inflammatory protein (MIP)-2. and activation of mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) 1/2, c-Jun amino terminal kinases and p38 mitogen-activated protein kinase, and NF-kappa B activation in RAW264.7 cells. Sauchinone decreased the production of TNF-alpha, but not MIP-2 production in RAW264.7 cells stimulated with LPS. Sauchinone also decreased c-Raf-MEK1/2-ERK1/2 phosphorylation and NF-kappa B activation in RAW264.7 cells stimulated with LPS. Our results show that sauchinone inhibits LPS-induced TNF-alpha expression in macrophages by suppression of NF-kappa B activation via ERK1/2 pathway, which may constitute anti-inflammatory effects of sauchinone. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/22371http://dx.doi.org/10.1016/j.intimp.2010.06.001
ISSN
1567-5769
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약학대학 > 약학부 > Articles
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