Structural basis for the negative regulation of bacterial stress response by RseB

Title
Structural basis for the negative regulation of bacterial stress response by RseB
Author(s)
김동영권은주[권은주]최종근[최종근]황혜연[황혜연]김경규[김경규]
Keywords
ESCHERICHIA-COLI; PROTEOLYSIS; CLEAVAGE; DEGS; INHIBITION; SOFTWARE; PROTEASE; BINDING; DOMAIN; MODEL
Issue Date
201006
Publisher
WILEY-BLACKWELL
Citation
PROTEIN SCIENCE, v.19, no.6, pp.1258 - 1263
Abstract
The sigma E-dependent stress response in bacterial cells is initiated by the DegS-and RseP-regulated intramembrane proteolysis of a membrane-spanning antisigma factor, RseA. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. In the crystal structure of the periplasmic domain of RseA bound to RseB, the DegS cleavage site of RseA is unstructured, however, its P1 residue is buried in the hydrophobic pocket of RseB, which suggests that RseB binding blocks the access of DegS to the cleavage site.
URI
http://hdl.handle.net/YU.REPOSITORY/22348http://dx.doi.org/10.1002/pro.393
ISSN
0961-8368
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE