Impact of systemic and local peritoneal inflammation on peritoneal solute transport rate in new peritoneal dialysis patients: a 1-year prospective study

Title
Impact of systemic and local peritoneal inflammation on peritoneal solute transport rate in new peritoneal dialysis patients: a 1-year prospective study
Author(s)
도준영조지형[조지형]허인경[허인경]김찬덕[김찬덕]박선희[박선희]유혜명[유혜명]육주민[육주민]최지영[최지영]최희정[최희정]박종원김용림[김용림]최혁준[최혁준]
Keywords
GLUCOSE DEGRADATION-PRODUCTS; ENDOTHELIAL GROWTH-FACTOR; CHRONIC-RENAL-FAILURE; MESOTHELIAL CELLS; MEMBRANE-TRANSPORT; FACTOR-BETA; COMORBIDITY; PREDICTORS; EFFLUENT; MARKERS
Issue Date
201006
Publisher
OXFORD UNIV PRESS
Citation
NEPHROLOGY DIALYSIS TRANSPLANTATION, v.25, no.6, pp.1964 - 1973
Abstract
Background. The association between peritoneal solute transport rates (PSTRs) and inflammatory markers in patients on peritoneal dialysis (PD) is still under investigation. We aimed to elucidate their relationship during the first year on PD. Methods. We performed a prospective observational study with 187 incident PD patients who were treated with either biocompatible solution (BCS) or conventional solution (CS). Peritoneal dialysate effluent (PDE) and blood samples for the markers and the calculation of mass transfer area coefficient of creatinine (MTAC) were performed at 1, 6 and 12 months after commencing PD. Results. Of the 187 enrolled patients, 110 completed a 1-year study protocol. All PDE markers [interleukin-6 (IL-6), transforming growth factor-beta (TGF-beta), TGF-beta-induced gene-h3 (beta ig-h3), vascular endothelial growth factor (VEGF)] except CA 125 increased over time, whereas PSTRs, high-sensitivity C-reactive protein (hs-CRP) and serum IL-6 levels did not change. Serum albumin and log PDE appearance rates (ARs) of IL-6, TGF-beta and CA 125 predicted MTAC. The Delta value (12-month minus 1-month) of PDE AR of IL-6 was correlated with those of all other PDE markers. Both 12-month IL-6 and Delta IL-6 ARs in PDE were highest in the upper Delta MTAC tertile. PSTRs in the CS group, unlike BCS, had a tendency to increase over time, demonstrating a time-by-group interaction. Solution type and MTAC were not associated with patient and technique survival. Conclusions. The change in PSTR during the first year of PD is related to PDE IL-6 AR, which may represent intraperitoneal inflammation; however, there does not seem to be a close association between PSTR and the degree of systemic inflammation.
URI
http://hdl.handle.net/YU.REPOSITORY/22341http://dx.doi.org/10.1093/ndt/gfp767
ISSN
0931-0509
Appears in Collections:
의과대학 > 내과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE