Synthesis of (-)-Paroxetine via Enantioselective Phase-Transfer Catalytic Monoalkylation of Malonamide Ester

Title
Synthesis of (-)-Paroxetine via Enantioselective Phase-Transfer Catalytic Monoalkylation of Malonamide Ester
Author(s)
김미현[김미현]박요한[박요한]정병선박형근[박형근]주상섭[주상섭]
Keywords
CARBON BOND FORMATIONS; ASYMMETRIC-SYNTHESIS; FORMAL SYNTHESIS; SUBSTITUTED PIPERIDINES; ENZYMATIC RESOLUTION; CONJUGATE ADDITIONS; PAROXETINE; INTERMEDIATE; LACTAMS; IMIDES
Issue Date
201006
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v.12, no.12, pp.2826 - 2829
Abstract
A new enantioselective synthetic method of (-)-paroxetine is reported. (-)-Paroxetine could be obtained in 15 steps (95% ee and 9.1% overall yield) from N,N-bis(p-methoxyphenyl)malonamide tert-butyl ester via the enantioselective phase-transfer catalytic alkylation and the diastereoselective Michael addition as the key steps.
URI
http://hdl.handle.net/YU.REPOSITORY/22321http://dx.doi.org/10.1021/ol100928v
ISSN
1523-7060
Appears in Collections:
약학대학 > 약학부 > Articles
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