척수손상 흰쥐의 통증에 대한 지속적인 반복 경두개 자기자극의 효과
- 척수손상 흰쥐의 통증에 대한 지속적인 반복 경두개 자기자극의 효과
- Other Titles
- Effects of Continuous Repetitive Transcranial Magnetic Stimulation on Pain Response in Spinal Cord Injured Rat
- 배영경; 김수정; 서정민; 조윤우; 안상호; 강인순[강인순]; 박해운[박해운]; 황세진[황세진]
- Repetitive transcranial magnetic stimulation (rTMS); Spinal cord injury; Neuropathic pain; Cold allodynia
- Issue Date
- Annals of Rehabilitation Medicine, v.34, no.3, pp.259 - 264
- Objective: To investigate the effects of continuous repetitive transcranial magnetic stimulation (rTMS) on pain response in spinal cord injured rat.
Method: Forty Sprague-Dawley rats (200∼250 grams, female) were used. Thoracic spinal cord (T9) was contused using New York University (NYU) spinal cord impactor. Ten gram weight rod was dropped from a height of 25 mm to produce spinal cord contusion model with moderate injury. The animals were randomly assigned to two groups: one exposed to real magnetic stimulation (real-rTMS group) and the other not exposed to magnetic stimulation (sham- rTMS group). rTMS was applied for 8 weeks. To assess the effect of continuous rTMS on below-level pain responses after spinal cord injury (SCI), the hindpaw withdrawal response for thermal stimuli, cold stimuli and mechanical stimuli were compared between two groups.
Results: Behavioral response for pain showed that hindpaw withdrawal response for cold stimuli was reduced significantly from 4 weeks after SCI in real-rTMS group compared with sham group (p＜0.05).
Conclusion: These results suggest that continuous rTMS may have beneficial effects on attenuation of cold allodynia after SCI, and it might be an additional non-invasive therapeutic method in patients with chronic neuropathic pain after SCI. (J Korean Acad Rehab Med 2010; 34: 259-264)
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