척수손상 흰쥐의 통증에 대한 지속적인 반복 경두개 자기자극의 효과

Title
척수손상 흰쥐의 통증에 대한 지속적인 반복 경두개 자기자극의 효과
Other Titles
Effects of Continuous Repetitive Transcranial Magnetic Stimulation on Pain Response in Spinal Cord Injured Rat
Author(s)
배영경김수정서정민조윤우안상호강인순[강인순]박해운[박해운]황세진[황세진]
Keywords
Repetitive transcranial magnetic stimulation (rTMS); Spinal cord injury; Neuropathic pain; Cold allodynia
Issue Date
201006
Publisher
대한재활의학회
Citation
Annals of Rehabilitation Medicine, v.34, no.3, pp.259 - 264
Abstract
Objective: To investigate the effects of continuous repetitive transcranial magnetic stimulation (rTMS) on pain response in spinal cord injured rat. Method: Forty Sprague-Dawley rats (200∼250 grams, female) were used. Thoracic spinal cord (T9) was contused using New York University (NYU) spinal cord impactor. Ten gram weight rod was dropped from a height of 25 mm to produce spinal cord contusion model with moderate injury. The animals were randomly assigned to two groups: one exposed to real magnetic stimulation (real-rTMS group) and the other not exposed to magnetic stimulation (sham- rTMS group). rTMS was applied for 8 weeks. To assess the effect of continuous rTMS on below-level pain responses after spinal cord injury (SCI), the hindpaw withdrawal response for thermal stimuli, cold stimuli and mechanical stimuli were compared between two groups. Results: Behavioral response for pain showed that hindpaw withdrawal response for cold stimuli was reduced significantly from 4 weeks after SCI in real-rTMS group compared with sham group (p<0.05). Conclusion: These results suggest that continuous rTMS may have beneficial effects on attenuation of cold allodynia after SCI, and it might be an additional non-invasive therapeutic method in patients with chronic neuropathic pain after SCI. (J Korean Acad Rehab Med 2010; 34: 259-264)
URI
http://hdl.handle.net/YU.REPOSITORY/22267
ISSN
2234-0645
Appears in Collections:
의과대학 > 병리학교실 > Articles
의과대학 > 재활의학교실 > Articles
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