Fatty Acid Synthase Inhibitory Activity of Dibenzocyclooctadiene Lignans Isolated from Schisandra chinensis

Title
Fatty Acid Synthase Inhibitory Activity of Dibenzocyclooctadiene Lignans Isolated from Schisandra chinensis
Author(s)
나민균Tran Manh Hung [Tran Manh Hung ]오원근[오원근]민병선[민병선]이승호배기환[배기환]
Keywords
BREAST-CANCER CELLS; FLAVONOIDS; APOPTOSIS; GROWTH
Issue Date
201007
Publisher
JOHN WILEY & SONS LTD
Citation
PHYTOTHERAPY RESEARCH, v.24, pp.S225 - S228
Abstract
Inhibition of fatty acid synthase (FAS) has been proposed to be a new therapeutic target for the treatment of cancer and obesity. In our preliminary screening study on the FAS inhibitory activity, a n-hexane soluble fraction prepared from the fruit of Schisandra chinensis (Schisandraceae) was found to inhibit FAS activity at 100 mu g/mL. Nine dibenzocyclooctadiene lignans were isolated from the active fraction and were evaluated for their inhibitory effect on FAS for the first time. The compounds possessing a benzoyl or tigloyl group in the dibenzocyclooctadiene skeleton entirely inhibited the FAS activity in a dose dependent manner. The findings may be partially related to the anticancer effect of the medicinal plant, suggesting a further study on the anticancer potential of dibenzocyclooctadiene derivatives. Copyright (C) 2010 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/22185http://dx.doi.org/10.1002/ptr.3149
ISSN
0951-418X
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE